Truveta outlines a path toward a continuously learning healthcare system in new peer-reviewed publication

New JAMIA Open paper describes how health systems, artificial intelligence, and continuously updated clinical data can transform routine care into living evidence

BELLEVUE, Wash., Aug. 06, 2026 (GLOBE NEWSWIRE) -- Truveta announced the publication of a new peer-reviewed paper in JAMIA Open describing how health systems, artificial intelligence, and continuously updated clinical data can help realize a long-standing vision in medicine: a healthcare system that learns from every patient, every day.

The paper, "From fragmented records to living evidence: health system-governed, artificial intelligence-driven, continuously updated real-world clinical data from Truveta," provides a comprehensive overview of the Truveta platform, including its health system governance model, AI-powered data harmonization, regulatory-grade quality framework, and continuously updated real-world data representing more than 140 million patients.

For decades, healthcare has generated extraordinary amounts of knowledge through everyday patient care. Yet much of that learning has remained trapped in disconnected systems, fragmented records, and slow evidence-generation processes. The publication describes how Truveta was designed to transform routine care into continuously updated evidence that can accelerate research, inform decisions, and improve patient outcomes.

"For decades, healthcare has aspired to become a learning system, where the experiences of patients help improve care for future patients," said Johnathan Lancaster, MD, PhD, President and Chief Scientific Officer at Truveta. "This publication describes how health systems, comprehensive clinical data, and advances in artificial intelligence can work together to make that vision a reality. By transforming routine care into continuously updated evidence, we can help ensure that every patient encounter contributes to better knowledge, better decisions, and ultimately better care for the next patient."

Published by researchers from Truveta, the paper details how leading US health systems contribute daily clinical data that are de-identified, harmonized, and transformed into research-ready real-world evidence. The publication highlights several capabilities designed to support continuous learning, including:

• Learning from every patient: More than 140 million de-identified patient journeys representing diverse populations, care settings, and geographies across the United States.
• Learning in real time: Daily data updates that help researchers and health systems understand emerging trends, treatment patterns, and outcomes faster.
• Learning from all forms of clinical knowledge: AI-powered extraction of insights from physician notes, imaging reports, pathology narratives, and other unstructured data sources.
• Learning with trust: Health system governance combined with rigorous privacy, security, ethics, and data quality practices.

As described in the publication, Truveta has supported hundreds of scientific publications spanning treatment effectiveness, post-market surveillance, vaccine safety, healthcare utilization, health equity, and public health monitoring.

"Healthcare doesn't have a data problem. It has a learning problem," said Michael Simonov, MD, Chief Product Officer at Truveta and co-author of the paper. "Every day, patients, clinicians, and health systems generate valuable lessons about disease, treatment, and outcomes. The challenge is turning those individual experiences into collective intelligence that can benefit everyone. This publication describes how Truveta helps transform fragmented records into living evidence, enabling healthcare to learn continuously and improve faster for patients, clinicians, researchers, and public health leaders."

The authors conclude that Truveta represents a significant advance in real-world evidence generation by combining health system governance, large-scale clinical data, daily updates, and AI-powered harmonization into a scalable model for continuous learning and improvement.

About the study

The full paper, "From fragmented records to living evidence: health system-governed, artificial intelligence-driven, continuously updated real-world clinical data from Truveta," is available in JAMIA Open.

About Truveta

Truveta transforms healthcare into intelligence. Built with and owned by US health systems united by a mission of Saving Lives with Data, Truveta powers breakthrough discoveries, regulatory-grade evidence, and AI that improves patient care.

Truveta membership includes: Providence, Advocate Health, Trinity Health, Tenet Healthcare, Northwell Health, AdventHealth, Baptist Health of Northeast Florida, Baylor Scott & White Health, Bon Secours Mercy Health, CommonSpirit Health, Hawaii Pacific Health, HealthPartners, Henry Ford Health System, HonorHealth, Inova, Lehigh Valley Health Network, MedStar Health, Memorial Hermann Health System, MetroHealth, Novant Health, Ochsner Health, Premier Health, Saint Luke’s Health System, Sanford Health, Sentara Healthcare, Texas Health Resources, TriHealth, UnityPoint Health, Virtua Health, and WellSpan Health.

Ellie Lampton
Truveta
news@truveta.com